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The purpose of this study was to determine whether there was any changes in mandibular condylar cartilage due to administration of various concentration of fluoride. The thickness of each layers were measured with light microscope and calcium contents of outmost layer of femur also determined with ICP Emission Spectrophotometer. All collected samples were analyzed by analysis of variance with Duncan multiple range test and analysis of covariance also adapted by setting weight as covariable. Among three layers of rat condylar cartilage, fibrous and proliferation layers were not affected by fluoride administration, but hypertrophic layers in the rats administrated 10, 30, 100 and 200ppm of fluoride for both 6 weeks and 9 weeks showed a significant increase in thickness compared with control group. Statistical analysis revealed that the total thickness of cartilage layers of fluoride administrated groups were increased significantly as compared with these in the control group. It showed that the increases of both cartilage cell size and number in fluoride treated groups when compared with these in control animals. The calcium contents of outmost surface of femur in the animals administrated 10, 30, 100ppm of fluoride for both six weeks and nine weeks were increased, but decreased in the animals in 200ppm groups.
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